[su_dropcap style=”flat”]c[/su_dropcap]collacone® is a wet-stable and moldable cone made of natural collagen. It was specifically developed and designed for application in fresh extraction sockets, to support the natural healing of the socket. The application of collacone® into the socket supports the stabilization of the formed blood coagulum and helps to control bleeding, while its form-fitted cone shape  protects the wound area from food and bacteria. collacone® resorbs completely within about 2-4 weeks.

Blood clot protection and natural hemostasis

After tooth removal, the healing of an extraction socket requires the formation and maturation of a blood clot, followed by the infiltration of fibroblasts that replace the coagulum. The spongy structure of collacone® provides an ideal structure for the adhesion of thrombocytes, fibroblasts, and osteoblasts. Fine blood vessels grow into and through the cone; as a result, the preliminary tissue formed in the alveole is supplied with oxygen, nutrients, and the essential signaling molecules, which support its bony regeneration. collacone® application is particularly beneficial in hemostatic compromised patients to prevent postoperative bleeding events.


Implantology, Periodontology and Oral and CMF

The collacone® is indicated wherever capillary, venous, small arterial and diffuse seeping bleedings must be stopped, and where conventional means of hemorrhage control are either inadequate or technically difficult and time-consuming.
The collacone® is used as a hemostatic agent following tooth extractions or harvesting of biopsies, soft tissue and bone transplants.

  • Closure of extraction sockets
  • Biopsy sites
  • Minor oral wounds
  • Control and stop of bleeding in extraction sockets or biopsy sites
  • Internal sinus lift


  • Resorption within two to four weeks
  • Stabilization of blood clot and efficient local hemostasis
  • Maintains integrity in the presence of blood and during application
  • Wound protection
  • Three-dimensional matrix for tissue ingrowth
  • Controlled wound healing process
  • Natural collagen cone


Support of socket healing with collacone®


Fernando Rojas-Vizcaya,
Castellon, Spain

A new study evaluating the efficacy of collacone® to prevent post-operative bleeding in hemostatic compromised patients after tooth extraction was published in May this year.

Prevention of post-operative bleeding in hemostatic compromised patients using native porcine collagen fleeces-retrospective study of a consecutive case series. Zirk M, Fienitz T, Edel R, Kreppel M, Dreiseidler T, Rothamel D. Oral Maxillofac Surg. 2016 May 2. [Epub ahead of print]



Safe and natural product

collacone® is produced of porcine dermis by a standardized, controlled purification process . The dermis is carefully cleaned by several wet-chemical purification steps, lyophilized and sterilized by gamma irradiation. The unique production process guarantees a safe end-product free from cells and chemical residues.
Collagen is a highly versatile material that, due to its low immunogenicity and superior biocompatibility and that of the degraded end-products, is widely employed in biomedical and pharmacological applications [1] The natural hemostatic function of the collagen together with its complete resorption make collacone® an ideal product to apply in fresh extraction sockets and cover wounds, helping control the bleeding and stabilizing the wound.

Natural hemostatic function of collagen

collacone_-hemostatic_functionDamage to the blood vessel wall leads to subendothelial collagen release. The collagen directly or indirectly interacts with the surface receptors on thrombocytes. The binding of collagen initiates a reaction cascade leading to transformation and aggregation of the thrombocytes. Additionally, the thrombocytes are cross-linked by fibrinogen. The resulting (white) thrombus initially stabilizes the wound [2]. Accordingly, collagen membranes and sponges support the formation of a blood coagulum and contribute to a rapid stabilization of the wound area. Due to their hemostatic effect, collagen sponges and cones can be used for stabilization of biopsy harvesting sites or covering of minor oral wounds and extraction sockets, respectively.



Prevention of bleeding hemostatic compromised patients

Medication with anticoagulant drugs (i.e. heparin or warfarin) poses a risk for patients of bleeding following tooth extraction. Local hemostatic agents like collagen fleeces can prevent postoperative bleeding without the need to pause the anticoagulant therapy [3]. A retrospective study with 200 anticoagulated patients showed a very low rate of bleedings following application of collagen sponges (collacone® and Jason® fleece) in fresh extraction sockets [4].

Protection of the socket and blood clot

The form-fitted cone shape of collacone® protects the wound area from entry of food and bacteria. Furthermore, the spongy collagen structure of the cone encourages coagulum formation and provides an ideal structure for the adhesion of thrombocytes, fibroblasts and osteoblasts. Fine blood vessels grow into and through the cone, connecting it to the surrounding tissue. Consequently, the preliminary tissue formed in the alveole is supplied with oxygen and nutrients and important signaling molecules supporting its bony regeneration.


Application of collacone®

Generally, dry application of the collacone® is recommended, because soaking or moistening prior to implantation may impair its hemostatic properties. At the defect site, the spongy cone rapidly soaks up blood. The collacone® maintains integrity in the presence of blood and during application.

Rapid uptake of blood and liquids

Due to its hydrophilic properties and highly porous structure, the collacone® quickly absorbs blood. The collacone® can also be loaded with liquid antibiotics for application in infected sites. High resolution pictures show the spongy structure and three-dimensional fiber network of collacone®.



Early implantation

According to the early implantation procedure, the implant is placed after tooth extraction, before the bony regeneration takes place within the socket. Typically, an early implantation is performed about 4-8 weeks after tooth extraction; at this point, the healing of the soft tissue is completed and potential inflammations have disappeared. The natural healing of the socket may be supported by applying collacone® into the socket to support the stabilization of the formed blood coagulum and protect the wound area from food and bacteria. Although the bone volume is usually adequate after 4-8 weeks (since the resorption of the alveolar bone has not yet started), any existing bony defect of the alveole may be treated at the moment of implantation.

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Product Specifications

Art.-No. Dimension Content
511112 ~16 mm height,
width on top ~11 mm,
bottom width ~7 mm
12 pieces (single sterile units)


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[1] Patino, M. et al., 2002. Collagen as an Implantable Material in Medicine and Dentistry. J Oral Implant, 28(5), pp. 220 – 225.; Geiger, M. Et al. 2003. Collagen sponges for bone regeneration with rhBMP-2. Ad. Drug Del. Rev., Volume 55, pp. 1613 – 1629.
[2] Nuyttens et al.  2011. Platelet adhesion to collagen. Thromb Res 127 Suppl 2:S26-9
[3] Morimoto Y. et al  2008. Hemostatic management of tooth extractions in patients on oral antithrombotic therapy. J Oral Maxillofacial Surg 66:51.

[4] Zierk M. et al. Prevention of post-operative bleeding in hemostatic compromised pateints using native porcine collagen fleeces – restrospective study of a consecutive case series. Oral Maxillofac Surg. 2016 May 2.