collprotect® membrane

Native collagen membrane

 

ccollprotect® membrane is a native collagen membrane made of porcine dermis, which is intended for dental bone and soft tissue regeneration. The natural, hemostatic effect of collagen enables early wound stabilization and supports the natural healing. Moreover, the collprotect® membrane displays a good surface adaptation and tissue integration and is ideal for most indications where an intermediate stability and easy handling are required.

 

Dense and open porous collagen structure

The validated and controlled manufacturing process removes all cells and non-collagenous components, while the natural collagen structure of the tissue of origin is being preserved. collprotect® is a uniform membrane with a thickness of about 0.4 mm. Its three-dimensional structure with open pores facilitates the fast ingrowth of blood vessels and accelerates integration into the surrounding tissue [1,2]. The general compactness, however, prevents cells from fast migration into the defect area [3].

CLINICAL APPLICATION

Block augmentation with maxresorb®, collprotect membrane & autologous bone blocks

Prof. Daniel Rothamel
Heinrich Heine University, Dusseldorf, Germany

Regeneration of an intrabony defect using collprotect® membrane and cerabone® [2]

Dr. Raluca Cosgarea & Prof. Anton Sculean, University Cluj-Napoca, Romania and University Bern, Switzerland

PROPERTIES

  • Natural, dense, open porous collagen structure
  • No artificial cross-linking
  • Natural rough surface for cell adhesion/migration
  • Open pores facilitates blood vessel ingrowth and support angiogenesis
  • Controlled resorption
  • Natural collagen supports blot clot formation and wound healing
  • Easy application dry or wet

UPCOMING EVENTS

Kuwait, 4. Nov. 2017

Dr. Péter Windisch: botiss academy Kuwait

Hong Kong, 9. Nov. 2017

Dr. Stjepan Siber: botiss academy Hong Kong

More Events on botiss-academy

INDICATIONS

collprotect® membrane offers a mid-term barrier function, making our membrane of choice for the regeneration of smaller and middle-size defects and periodontal defects. However, as an allrounder collprotect® membrane can be used in various indications.

Implantology, Periodontology and Oral and CMF Surgery

  • Protection and coverage of the Schneiderian membrane
  • Sinus lift
  • Socket preservation
  • Horizontal ridge augmentation
  • GBR and GTR with simultaneous use of bone graft
  • Fenestration/dehiscence defects
  • Intraosseous defects (I-III walls)
  • Furcation defects (class I-II)

Poster/Articles

  • Cosgarea R, Juncar R, Tristiu R, Arweiler N, Lascu L, Sculean A. Treatment of intrabony defects.  Poster No. 2762. International Association for Dental Research (IADR) Boston 2015.
  • Cosgarea R, Arweiler N, Sculean A. Up-date zur regenerativen paradontalen Therapie. Der Freie Zahnarzt 2014; 58(9):62-71. LINK
  • Panagiotou D, Özkan Karaca E, Dirikan İpçi Ş, Çakar G, Olgaç V, Yılmaz S. Comparison of two different xenografts in bilateral sinus augmentation: radiographic and histologic findings. Quintessence Int. 2015; 46(7):611-9. LINK
  • Rothamel D, Török R, Neugebauer J, Fienitz T, Scheer M, Kreppel M, Mischkowski R and Zöller J. Current issues in soft- and hard-tissue augmentation. EDI Journal 1/2012. P.62. LINK
  • Rothamel D, Fienitz T, Benner M, Happe A, Kreppel M, Scheer M, and Zöller J. Biogegradation pattern of native and cross-linked collagen matrices- an experimental study in rats. Poster No. 449. 20th Annual Scientific Meeting of the European Association of Osseointegration (EAO) Athens 2011.
  • Stähli A, Miron RJ, Bosshardt DD, Sculean A, Gruber R. Collagen Membranes Adsorb the Transforming Growth Factor-β Receptor I Kinase-Dependent Activity of Enamel Matrix Derivative. J Periodontol. 2016; 87(5):583-90. LINK
DETAILS

SPECIFIC FACTS

High safety

The certified manufacturing process of the collprotect® membrane ensures the removal of cells, non-collagenous proteins and potential immunogenic components including bacteria and viruses. Therefore, this membrane is a safe medical device that is regulated according to the EC guidelines with a standardized manufacturing process based on international standards (EN ISO13485).

Native 3-D collagen structure

collprotect® membrane is a native collagen membrane derived from porcine skin (dermis). The dermis is a deeper part of the cutaneous layer and a strong and flexible tissue based on collagen type I and III. The natural structure and biomechanical properties of the dermis are preserved during the manufacturing process. collprotect® membrane presents a dense but porous collagen structure that prevents soft tissue ingrowth, while promoting early revascularization [1,2,3].
The structural unity of the membrane therefore allows placement of both sides to face the defect without affecting its barrier function.

collprotect_membrane_semcollprotect_membrane_sem2

Fast angiogenesis

Bild9

collprotect® membrane exhibits areas of a fibrillary structure within its dense collagen fiber network. These pores originate from the hair follicles of the porcine skin and become recognizable once the hairs have been removed. These pores facilitate the early ingrowth of blood vessels into the defect area through the membrane [1].

Easy application/handling

The collprotect® membrane can be applied dry or after rehydration in sterile saline solution or patients own blood. Under dry conditions, the relative stiffness of the membrane allows an upright positioning into the defect or the socket, while filling it with a bone grafting material. After rehydration, the membrane becomes flexible, can easily be placed over the augmentation site, and adapts very well to the surface contours. Although collprotect® membrane supports suturing or pinning, in most cases a fixation is not required due to excellent adhesion- and adaptation properties.

Avoidance of exposure

A complete coverage of the defect is recommended at any time, since fast bacterial resorption significantly reduces the barrier and therefore the regenerative function of the collagen membrane. In unstable soft tissue situations, if a wound dehiscence is to be expected, or if the soft tissue does not allow primary closure, a Jason® fleece may be used to cover and protect the collprotect® membrane as well as the healing area.

Product Specifications

Art.-No.SizeContent
60152015 x 20 mm1 × membrane
60203020 × 30 mm1 × membrane
60304030 × 40 mm1 × membrane

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LITERATURE

[1] Rothamel D, Török R, Neugebauer J, Fienitz T, Scheer M, Kreppel M, Mischkowski R and Zöller J. Current issues in soft- and hard-tissue augmentation. EDI Journal 1/2012. p.62. LINK
[2] Stähli A, Miron RJ, Bosshardt DD, Sculean A, Gruber R. Collagen Membranes Adsorb the Transforming Growth Factor-β Receptor I Kinase-Dependent Activity of Enamel Matrix Derivative. J Periodontol. 2016; 87(5):583-90. LINK
[3] Rothamel D, Fienitz T, Benner M, Happe A, Kreppel M, Scheer M, and Zöller J. Biogegradation pattern of native and cross-linked collagen matrices- an experimental study in rats. Poster No. 449. 20th Annual Scientific Meeting of the European Association of Osseointegration (EAO) Athens 2011.