Natural three-dimensional collagen
network of Jason® membrane

Jason^® membrane is a native collagen membrane derived from porcine pericardium (strong, elastic membrane that circumvents and protects the heart). During the extensive wet chemical cleaning procedure of the manufacturing process, all antigenic components are removed, but the natural structure of aligned collagen fibers and interconnected pores [1,2] is preserved leading to slow degradation and prolonged stability.

According to the biomechanical properties of native pericardium, which is able to withstand significant volume changes and forces, the Jason® membrane exhibits a remarkable tear resistance and stability. Accordingly, Jason^® membrane is characterized by an outstanding multi-directional tear resistance that allows easy pinning and suturing without rupturing and very good surface adaption without stickiness upon rehydration.

The thickness of a membrane does not necessarily correspond to its barrier function and resorption time. Jason^® membrane offers a very low thickness of 0.05-0.35 mm, but nevertheless exhibits a prolonged resorption time as proven by animal experiments [3].

The Jason^® membrane is a native collagen membrane, meaning the natural collagen structure of the pericardium is preserved during the manufacturing process. Due to the comb-like and multilayered collagen structure with an increased content of collagen type III, the Jason® membrane shows a slow
degradation [2,3]. This ensures a prolonged barrier function, making
the Jason® membrane our recommended choice particularly for
large augmentative procedures.

Jason^® membrane is not artificially cross-linked by chemical or physical treatment. Cross-linking slows down membrane degradation properties and negatively affects the biocompatibility, tissue integration, and revascularization as shown for other collagen membranes by an animal study [4].

In opposite to chemically or physically cross-linked membranes, Jason^® membrane is characterized by a naturally long barrier function based on its origin from pericardial tissue [3]. The fibres of the original pericardial tissue are naturally cross-linked, their structure being preserved during the entire production process, thus generating a natural collagen membrane with an extended degradation time [1,2,3].

The Jason^® membrane is hydrophilic and rapidly rehydrates in blood. The excellent ability of the Jason^® membrane to adhere to the defect site without sticking together when folded guarantees optimal handling. The excellent adhesion to the defect site makes additional fixation of the Jason^® membrane unnecessary in most cases. If wished or necessary, the multidirectional strength and tear resistance of Jason^® membrane permits the use of sutures and other fixation methods (e.g. pinning).