maxresorb® inject

Four-phasic injectable bone graft


[su_dropcap style=”grey”]m[/su_dropcap]maxresorb® inject is a unique four-phasic injectable bone graft paste with controlled resorption properties. The water-based gel contains active HA nanoparticles mixed together with small maxresorb granules particles (60% HA/40% β-TCP). The HA nanoparticles (size 15–50 nm) provide an extensive surface area for cellular interactions, which lead to rapid resorption, thereby promoting new bone formation. In addition, the maxresorb® granules contained in the gel help maintain the volume over time.


Easy handling

Owing to its specific composition, the viscous properties of maxresorb® inject allow perfect shaping, molding, fitting and complete bonding to the surrounding bone surface of the defect. maxresorb® inject is a non-hardening and ready-to-use bone paste. The syringe design allows direct and easy application to the defect site. Once applied, maxresorb® inject is gradually replaced by new bone.


maxresorb®  inject is designed for the regeneration of smaller defects that do not require extra volume stability. In these cases, the particular composition of maxresorb® inject and its active HA nanoparticles offer an extensive surface area that promotes cell-biomaterial interactions, thus leading to a rapid cellular resorption of the particles and accelerating the formation of new bone.


Implantology, Periodontology and Oral and CMF Surgery

  • Sinus lift
  • Intraosseous defects
  • Socket preservation
  • Osseous defects
  • Regeneration in small/contained defects
  • Gap-filling in combination with other bone substitutes


  • Synthetic, resorbable and safe
  • Ready to use/easy handling
  • Viscous and moldable
  • Non-hardening
  • Optimal adaptation to surface contours
  • Active HA nanoparticles
  • Contains 60% HA/40% β-TCP


Internal sinus lift with maxresorb® inject

Dr. Frank Kistler,
Landsberg am Lech, Germany

Immediate implantation with maxresorb® inject

Dr. Damir Jelušic,
Opatija, Croatia



  • Comparison of the rates of bone regeneration in sinus lift grafting with a calcium phosphate paste between the 6th and the 9th month: a clinical case. Georgi Papanchev et al., Scripta Scientifica Medicinae Dentalis, vol. 1, No 1, 2015, 41-49. LINK
  • Guided Bone Regeneration and Simultaneous Implant Placement. Stefan Peev et al. International Journal of Science and Research. Vol 5, 2; Feb 2016. LINK
  • Influence of maxresorb® inject (60% hydroxyapatite and 40% β-tricalcium phosphate) on bone healing in rats. R. Schnettler, Surgical Hospital and Polyclinic for Trauma Surgery University Hospital Gießen and Marburg. Scientific report, 2011 (available upon request)
  • Bone regeneration following socket preservation using different bone substitute materials. A pilot study in dogs. Rothamel and D. Ferrari, University of Cologne/University of Duesseldorf. Scientific report, 2009 (available upon request)


Advantages of injectable pastes

The development of injectable bone regeneration materials started with the discovery of calcium cements in the 90’s [1]. Cements are produced by mixing calcium phosphate powder with an aqueous solution. Cements create the possibility for several minimal invasive therapies of bony defects and offer an easier handling in many indications. Following application, the hardening occurs in vivo.

Putties, like maxresorb® inject, offer two significant advantages over cements: Firstly, their increased porosity allows for the ingrowth of blood vessels and bone tissue, resulting in a fast and complete integration into new bone matrix and a rapid natural remodeling; secondly, owing to their large surface area, the nano/micro HA particles exhibit a high biologic activity resulting in an osteostimulative effect. Nano/micro HA particles support the adhesion of bone cells, which promote a fast particle degradation, offering thus additional space for the ingrowth of new bone tissue.

Non-hardening paste: rapid vascularization

Unlike other products, maxresorb® inject is not hardening in situ. Thus, the easy-to-handle paste-like structure of maxresorb® inject enables a very fast vascularization of the defect while providing an osteoconductive scaffold for the migration of bone forming cells. Hardening bone putties are often associated with low tissue integration due to the formation of a solid body that prevents cell and vessel penetration into the material.
Due to it’s non-hardening characteristics, maxresorb® inject always has to be covered with a barrier membrane to stabilize the material and facilitate undisturbed bony regeneration.


Are there limitations for the clinical application of maxresorb® inject

maxresorb® inject is predominantly composed of a nano-HA gel (83.5%). Due to the abundance of nano-HA particles within the material, and thereby their large surface area, the nano-HA particles promote cellular interactions that in turn results in accelerated new bone formation, as well as a fast cellular resorption of the particles. The embedded maxresorb® particles help to maintain the volume to a certain extent, but due to the relatively low content of maxresorb® particles within the paste, maxresorb® inject paste does not provide sufficient stability for predictable regeneration of larger defects. To increase stability, maxresorb® inject can be mixed with a slowly resorbable material such as cerabone® or maxresorb®.

What happens with the material after implantation?

Directly following application the water will dissolve leaving behind nano-HA particles and HA/beta-TCP granules. The nano-HA particles exhibit a high biologic activity because of their large surface, meaning a strong interaction with bone forming cells as well as macrophages and osteoclasts. The small particles are resorbed very fast (~6-8 weeks), but also promote fast new bone formation in the resulting free spaces. At the same time the beta-TCP/HA granules provide a scaffold for the migration of bone forming cells and the deposition of new bone matrix. Beta-TCP will resorb within ~3-6 months, HA within ~2-3 years.

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Product Specifications

maxresorb® inject
Art.-No. Unit
22005 1 x syringe 1 × 0.5 ml
22010 1 x syringe 1 × 1.0 ml
22025 1 x syringe 1 × 2.5 ml

[1]  Brown and Chow (1985). Dental restorative cement pastes. US Patent 4’518’430, American Dental Association Health Foundation, USA