maxresorb®

Innovative biphasic calcium phosphate

mmaxresorb® is an innovative, safe, reliable, and fully synthetic bone substitute material that is characterized by controlled resorption properties and outstanding handling characteristics.

maxresorb® is composed of 60% slowly resorbing hydroxyapatite (HA) and 40% fast resorbing beta-tricalcium phosphate (β-TCP) [1,2]. The unique synthesis-based production process ensures a completely homogenous distribution of both mineral phases. The peculiar composition of maxresorb® promotes fast formation of new vital bone, while ensuring a long-term mechanical and volume stability.

IDEAL OSTEOCONDUCTIVE PROPERTIES

The osteoconductivity of maxresorb® is based on a matrix of interconnecting pores, a very high overall porosity of approx. 80% as well as its rough surface. The nano-structured surface facilitates the adsorption of blood, proteins, and stem cells and promotes cell differentiation and osseous integration. maxresorb® is thus an ideal scaffold for the migration of bone forming cells and binding of signaling molecules, which can accelerate tissue integration and regeneration [3].
maxresorb_bone

INDICATIONS

maxresorb® offers a reliable alternative to bovine bone in a variety of indications.

IMPLANTOLOGY, PERIODONTOLOGY AND ORAL AND CMF SURGERY

  • Sinus lift
  • Ridge augmentation
  • Intraosseous defects
  • Extraction sockets
  • Osseous defects
  • Furcation defects

PROPERTIES

  • 60% HA/40% β-TCP
  • Osteoconductive
  • Ultra-high interconnected porosity
  • Volume and mechanical graft stability
  • Safe, reliable and sterile
  • Very rough and hydrophilic surface
  • 100% synthetic and resorbable
CLINICAL APPLICATION

Dr. Steffen Kistler

Two-stage sinus lift with maxresorb® & collprotect® membrane

Prof. Dr. Daniel Rothamel

Sinus- and bone defect augmentation using maxresorb® and Jason® membrane

PD Dr. Jörg Neugebauer

Ridge augmentation by circular bone splitting and the use of maxresorb® and collprotect® membrane

Dr. Massimo Frosecchi

Socket preservation with maxresorb®
WEBINARS

Daniel Rothamel
Sinus lift procedures in the daily practice

David Botond Hangyasi
New materials in soft and hard tissue preservation

Andrea Scrascia
Surgical approach for soft tissue management

SURGERIES
YouTube

By loading the video, you agree to YouTube's privacy policy.
Learn more

Load video

Leandro Souza Pozzer
Immediate implant placement and temporization in the maxillary aesthetic zone with maxresorb®

YouTube

By loading the video, you agree to YouTube's privacy policy.
Learn more

Load video

Alfonso Caiazzo
Ice-cone cream technique with maxresorb® and collprotect® membrane

YouTube

By loading the video, you agree to YouTube's privacy policy.
Learn more

Load video

Andrea Pandolfi
Sinus lift using maxresorb® mixed with autologous bone

SPECIFIC DETAILS

SPECIFIC FACTS

Advantages of calcium phosphate materials

Having a similar chemical composition to that of the human bone, calcium phosphate ceramics are characterized by an excellent biocompatibility and no foreign body reactions. In particular, the advantages of calcium phosphates lie in their bioactive and resorption properties, which allow them to support the attachment and proliferation of bone cells that thus undergo a natural remodeling; this process involves osteoblasts and osteoclasts and is characterized by an initial integration of the material into the surrounding bone matrix and a gradual degradation. The most used calcium phosphates are hydroxyapatite (HA), alpha-tricalcium phosphate (α-TCP) and beta-tricalcium phosphate (β-TCP). Typically, HA shows the slowest solubility, therefore providing the highest stability, while β-TCP demonstrates a higher solubility and faster resorption kinetics. maxresorb® is a homogenous biphasic biomaterial containing 60% HA and 40% β-TCP.

 

maxresorb®: The ideal mix of hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP)

An ideal bone regeneration material should be slowly resorbed while new bone matrix is formed. The basic principle of maxresorb® and, more in general, of biphasic calcium phosphates, is to achieve a balance between the properties of hydroxyapatite (HA), which can be found years after the implantation, and beta-tricalcium phosphate (β-TCP), which is characterized by a quite fast resorption. Studies have shown that the optimal HA/beta-TCP ratio lies between 65:35 and 55:45 (Elaboration conditions influence physicochemical properties and in vivo bioactivity of macroporous biphasic calcium phosphate ceramics O. Gauthier, J. M. Bouler, E. Aguado J. Mat. Sci: Mat in Medicine 10 (1999) 199-204 Biphasic synthetic bone substitute use in orthopaedic and trauma surgery: clinical, radiological and histologica results. C. Schwartz, P, Liss, B, Jacquemaire J. Mat. Sci: Mat in Med 10 (1999) 821-825). Bone regeneration materials based on mixtures of HA and β-TCP have been successfully applied in dental regenerative surgery for more than 20 years.

Controlled full resorption of maxresorb®

In particular, pure beta-TCP resorbs very rapidly, e.g. within weeks from the initial insertion. In contrast, pure synthetic HA is characterized by a very slow resorption. Thus, the combination of HA and ß-TCP in maxresorb® offers the advantages of both materials, with a final biomaterial that shows excellent osteoconductivity. While the fast resorption of beta-TCP quickly offers space for new bone formation, the HA component provides volume stability for an extended time period. In addition, clinical evidence demonstrates a faster regeneration of defects treated with maxresorb® compared to bovine bone. Re-entry after ridge augmentation or sinus lift should be performed around 6–9 months post-op; this time can be shortened for the regeneration of smaller defects.

Advantages of maxresorb® compared to bovine bone substitutes
  • Since maxresorb® is 100% synthetic, the material has an unlimited availability, is reproducible and 100% safe (no risk of disease transmission).
  • Owing to its combination of 60% HA (slowly resorbed; highly active) and 40% β-TCP (rapidly resorbed; stable), maxresorb® is characterized by a fast resorption and complete, controlled resorption, which does not affect its volume stability.
  • As opposed to the natural structure of natural bovine substitutes, the micro-/macrostructure of maxresorb® is rationally designed to provide the ideal properties of a bone substitute, e.g., osteoconductivity, surface roughness, full remodeling, and hydrophilicity.
  • It’s application is not restricted by dietary or religious conflicts

Let us know YOUR COUNTRY and we will provide you with
YOUR right local
CONTACT PERSON!

Email to product-management@botiss.com!

Product Specifications

maxresorb® granules
Art.-No. Particle Size
Content
20005 0.5 – 1.0 mm (S) 1 x 0.5 ml
20010 0.5 – 1.0 mm (S) 1 x 1.0 ml
20105 0.8 – 1.5 mm (L) 1 x 0.5 ml
20120 0.8 – 1.5 mm (L) 1 x 2.0 ml
LITERATURE

.

[1] Gauthier et al. (1999). Elaboration conditions influence physicochemical properties and in vivo bioactivity of macroporous biphasic calcium phosphate ceramics. Journal of materials science. Materials in medicine 10:199–204.
[2] Schwartz et al. (1999). Biphasic synthetic bone substitute use in orthopaedic and trauma surgery: clinical, radiological and histological results. Journal of materials science. Materials in medicine 10:821–825
[3] Eriberto Bressan et al. Donor Age-Related Biological Properties of Human Dental Pulp Stem Cells Change in Nanostructured Scaffolds. PLOS One, Nov 2012, VOl 7, Issue 11; e49146.