Innovative biphasic calcium phosphate

mmaxresorb® is a safe, reliable and 100% synthetic bone graft substitute with controlled resorption properties and excellent handling characteristics. The fully synthetic nature of maxresorb® ensures its safety and eliminates any risk of infection.

Biphasic activity
maxresorb® shows an ideal homogenous, biphasic, composition of 60% hydroxyapatite (HA) and 40% beta-tricalcium phosphate (β-TCP) [1,2]. This composition is reflected into the controlled resorption behavior of maxresorb®  [3,4], which results in an initial integration of the particles followed by a complete resorption. While the fast resorption of β -TCP continuously increases the porosity of the material promoting tissue integration by allowing ingrowth of cells and blood vessels, the HA component provides volume stability for an extended time period.

Ideal osteoconductivity

The osteoconductivity of maxresorb® is achieved by a matrix of interconnected pores and a very high porosity of approx. 80%, with pore sizes ranging from 200-800 μm. The high macroporosity of maxresorb® ensures an efficient osteogenic cell growth and promotes the regeneration of vital bone. In turn, the microporosity and surface roughness of maxresorb® facilitate diffusion of biological fluids and cell attachment.

maxresorb® is thus an ideal scaffold for the migration of bone forming cells and binding of signaling molecules, which can accelerate tissue integration and regeneration [5].


Sinus Lift with maxresorb®/autologous bone

Dr. Andrea Pandolfi

Lateral augmentation

Dr. G. Bayer,
Landsberg am Lech, Germany


  • 100% synthetic and safe
  • Biphasic homogenous composition
  • Controlled full resorption/remodeling
  • Rough and hydrophilic surface
  • High porosity/interconnected pores


Our experts will answer all your questions at


Athen, 14th Feb., 2020

Prof. Adrian Kasaj, Dr. Ziv Mazor, Prof. Daniel Rothamel, Dr. Devorah Schwartz-Arad: bone & tissue days Athens 2020

Dublin, 5 March 2020

Prof. Giovanni Zucchelli: EFP-Workshop: Mucogingival esthetic surgery

More Events on botiss-academy


maxresorb® is a very versatile bone substitute that can be used in virtually all indications. It is therefore an ideal alternative to bovine bone especially in sites with a high regenerative potential such as the post-extraction socket and sinus.


Implantology, Periodontology and Oral and CMF Surgery

  • Sinus lift
  • Ridge augmentation
  • Intraosseous defects
  • Osseous defects
  • Furcation defects
  • Socket preservation


  • Histomorphometric and mineral degradation study of Ossceram: a novel biphasic B-tricalcium phosphate, in critical size defects in rabbits Calvo-Guirado et al. Clinical Oral Implants Research, 2012, 23, 667-675 (Ossceram nano private label). LINK
  • Assessment of Implant Stability Following Sinus Lift Procedures with Different Grafting Materials Damir Jelušić et al. Acta stomatol Croat. 2014;48(1):25-32. LINK
  • Donor Age-Related Biological Properties of Human Dental Pulp Stem Cells Change in Nanostructured Scaffolds Eriberto Bressan et al., PLOS ONE, 2012;7(11): 1-12. LINK


Advantages of calcium phosphate materials

Having a similar chemical composition to that of the human bone, calcium phosphate ceramics are characterized by an excellent biocompatibility and no foreign body reactions. In particular, the advantages of calcium phosphates lie in their bioactive and resorption properties, which allow them to support the attachment and proliferation of bone cells that thus undergo a natural remodeling; this process involves osteoblasts and osteoclasts and is characterized by an initial integration of the material into the surrounding bone matrix and a gradual degradation. The most used calcium phosphates are hydroxyapatite (HA), alpha-tricalcium phosphate (α-TCP) and beta-tricalcium phosphate (β-TCP). Typically, HA shows the slowest solubility, therefore providing the highest stability, while β-TCP demonstrates a higher solubility and faster resorption kinetics. maxresorb® is a homogenous biphasic biomaterial containing 60% HA and 40% β-TCP.


maxresorb®: The ideal mix of hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP)

An ideal bone regeneration material should be slowly resorbed while new bone matrix is formed. The basic principle of maxresorb® and, more in general, of biphasic calcium phosphates, is to achieve a balance between the properties of hydroxyapatite (HA), which can be found years after the implantation, and beta-tricalcium phosphate (β-TCP), which is characterized by a quite fast resorption. Studies have shown that the optimal HA/beta-TCP ratio lies between 65:35 and 55:45 (Elaboration conditions influence physicochemical properties and in vivo bioactivity of macroporous biphasic calcium phosphate ceramics O. Gauthier, J. M. Bouler, E. Aguado J. Mat. Sci: Mat in Medicine 10 (1999) 199-204 Biphasic synthetic bone substitute use in orthopaedic and trauma surgery: clinical, radiological and histologica results. C. Schwartz, P, Liss, B, Jacquemaire J. Mat. Sci: Mat in Med 10 (1999) 821-825). Bone regeneration materials based on mixtures of HA and β-TCP have been successfully applied in dental regenerative surgery for more than 20 years.

Controlled full resorption of maxresorb®

In particular, pure beta-TCP resorbs very rapidly, e.g. within weeks from the initial insertion. In contrast, pure synthetic HA is characterized by a very slow resorption. Thus, the combination of HA and ß-TCP in maxresorb® offers the advantages of both materials, with a final biomaterial that shows excellent osteoconductivity. While the fast resorption of beta-TCP quickly offers space for new bone formation, the HA component provides volume stability for an extended time period. In addition, clinical evidence demonstrates a faster regeneration of defects treated with maxresorb® compared to bovine bone. Re-entry after ridge augmentation or sinus lift should be performed around 6–9 months post-op; this time can be shortened for the regeneration of smaller defects.

Advantages of maxresorb® compared to bovine bone substitutes
  • Since maxresorb® is 100% synthetic, the material has an unlimited availability, is reproducible and 100% safe (no risk of disease transmission).
  • Owing to its combination of 60% HA (slowly resorbed; highly active) and 40% β-TCP (rapidly resorbed; stable), maxresorb® is characterized by a fast resorption and complete, controlled resorption, which does not affect its volume stability.
  • As opposed to the natural structure of natural bovine substitutes, the micro-/macrostructure of maxresorb® is rationally designed to provide the ideal properties of a bone substitute, e.g., osteoconductivity, surface roughness, full remodeling, and hydrophilicity.
  • It’s application is not restricted by dietary or religious conflicts

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Product Specifications

maxresorb® granules
Art.-No. Particle Size
20005 0.5 – 1.0 mm (S) 1 x 0.5 ml
20010 0.5 – 1.0 mm (S) 1 x 1.0 ml
20105 0.8 – 1.5 mm (L) 1 x 0.5 ml
20120 0.8 – 1.5 mm (L) 1 x 2.0 ml

[1]  Gauthier et al. (1999). Elaboration conditions influence physicochemical properties and in vivo bioactivity of macroporous biphasic calcium phosphate ceramics. Journal of materials science. Materials in medicine 10:199–204.
[2]  Schwartz et al. (1999). Biphasic synthetic bone substitute use in orthopaedic and trauma surgery: clinical, radiological and histological results. Journal of materials science. Materials in medicine 10:821–825
[3]  Daculsi (1998). Biphasic calcium phosphate concept applied to artificial bone, implant coating and injectable bone substitute. Biomaterials 19:1473–1478.
[4]  Ducheyne et al. (1993). The effect of calcium phosphate ceramic composition and structure on in vitro behavior. I. Dissolution. Journal of biomedical materials research 27:25–34
[5] Eriberto Bressan et al. Donor Age-Related Biological Properties of Human Dental Pulp Stem Cells Change in Nanostructured Scaffolds. PLOS One, Nov 2012, VOl 7, Issue 11; e49146.