soft tissue

The advantages of collagen

Several factors make collagen an optimal biologic material for use in hard and soft tissue regeneration.

One important characteristic is the excellent biocompatibility of collagen and its degradation products.
Collagen is widely distributed throughout the body, making up approx. 60% of all proteins within the gingival connective tissue. Due to their low antigenicity, animal collagens may be used in humans without causing tissue rejection.

Collagens are resistant to any unspecific proteolytic degradation and are only degraded by specific enzymes called collagenases. Collagens are involved in the primary hemostatic reaction. Thus, collagen based products help to stabilize the wound area and control bleeding and can support wound healing.

Another advantage of collagen is its chemotactic attraction of regenerative cells such as osteoblasts, gingival fibroblasts and periodontal ligament cells. Due to their advantageous properties, collagens are used as barrier membranes for GBR/GTR procedures, collagen matrices for soft tissue regeneration or collagen sponges and cones for stabilization of oral wounds and extractions sockets.

3D structure of a collagen fleece
Histology after subcutaneous implantation in rats demonstrating the presence of blood vessels within a collagen membrane

Advantages of collagen based materials

 

– Good biocompatibility
– Supports hemostasis
– Low antigenicity
– Degradation by specific enzymes
– Chemotactic attraction of regenerative cells

COLLAGEN MEMBRANES

 

Collagen membranes have been used in Guided Tissue Regeneration (GTR) and Guided Bone Regeneration (GBR) for many years. The principle of these techniques is based on the placement of a barrier membrane for separation of slowly proliferating regenerative cell types, such as osteoblasts and periodontal cells, from fast proliferating epithelial and connective tissue cells, thus enabling a predictable regeneration of lost tissue.

 

GTR aims at the regeneration of the periodontium. A barrier membrane is placed between the epithelium and the tooth, to provide space and time for regeneration of the periodontal ligament. In GBR procedures, membranes are normally applied in combination with a bone graft material. The membrane is placed over a bony defect filled with a bone graft material. The bone graft material prevents collapse of the membrane, and serves as an osteoconductive scaffold for ingrowth of bone and precursor cells. The barrier membrane prevents migration of bone graft particles into the oral cavity, and ingrowth of soft tissue into the defect area, thus enabling bony regeneration.

Guided Tissue Regeneration

botss_gtr

Guided Bone Regeneration

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botiss membranes provide excellent handling and stability

All botiss soft tissue products consist of natural porcine collagen originating from animals destined for the food industry, and certified according to EN ISO 22442.

 

botiss’ barrier membranes are native membranes, the natural properties of the original tissue (dermis or pericardium) being preserved during the production process. The inherent architecture of the collagen structure provides superior handling properties, such as tear resistance, tensile strength, and adaptation to surface contours, in comparison to “non-native” collagen membranes (i.e. made from a solution).

 

The particular multi-stage cleaning process effectively removes all non-collagenic proteins and antigenic components. The resulting membranes exhibit a natural three-dimensional collagen structure mainly composed of collagen type I and of collagen type III.

Natural three-dimensional collagen network of Jason® membrane
INDICATIONS

GBR/ Horizontal augmentation / Vertical augmentation / Ridge reconstruction / Socket preservation / Ridge preservation / Coverage of augmentation sites / Sinus lift / Protection and covering of Schneiderian membrane / Fenestration and dehiscence defects / Closure of extraction sockets / Biopsy sites / Minor oral wounds / GTR / Intraosseous defects (1 to 3 walls) / Furcation defects (class I and II) / Recession coverage / Soft tissue grafting / Broadening of attached gingiva

titanpinsettitan pin set

FOR MEMBRANE FIXATION

 

EDUCATION

Get to know more about the application of our soft tissue products and exchange your knowledge for your every day work with other specialists.

We proudly welcome you to the botiss regeneration system community. We invite you to share your experiences and suggestions with us, which are precious to further improve our products or develop new product concepts.

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