Collagens are resistant to any unspecific proteolytic degradation and are only degraded by specific enzymes called collagenases. Collagens are involved in the primary hemostatic reaction. Thus, collagen based products help to stabilize the wound area and control bleeding and can support wound healing.
Another advantage of collagen is its chemotactic attraction of regenerative cells such as osteoblasts, gingival fibroblasts and periodontal ligament cells. Due to their advantageous properties, collagens are used as barrier membranes for GBR/GTR procedures, collagen matrices for soft tissue regeneration or collagen sponges and cones for stabilization of oral wounds and extractions sockets.
GTR aims at the regeneration of the periodontium. A barrier membrane is placed between the epithelium and the tooth, to provide space and time for regeneration of the periodontal ligament. In GBR procedures, membranes are normally applied in combination with a bone graft material. The membrane is placed over a bony defect filled with a bone graft material. The bone graft material prevents collapse of the membrane, and serves as an osteoconductive scaffold for ingrowth of bone and precursor cells. The barrier membrane prevents migration of bone graft particles into the oral cavity, and ingrowth of soft tissue into the defect area, thus enabling bony regeneration.
botiss’ barrier membranes are native membranes, the natural properties of the original tissue (dermis or pericardium) being preserved during the production process. The inherent architecture of the collagen structure provides superior handling properties, such as tear resistance, tensile strength, and adaptation to surface contours, in comparison to “non-native” collagen membranes (i.e. made from a solution).
The particular multi-stage cleaning process effectively removes all non-collagenic proteins and antigenic components. The resulting membranes exhibit a natural three-dimensional collagen structure mainly composed of collagen type I and of collagen type III.